- Pop Collaboration With Vocals: Rich Woman, Robert Plant and Alison Krauss, track from "Raising Sand" (Rounder)
- Song of the Year: Viva La Vida, Guy Berryman, Jonny Buckland, Will Champion and Chris Martin, songwriters (Coldplay), track from Viva La Vida Or Death And All His Friends(Capitol Records; Publishers: Universal Music-MGB Songs)
- Country Performance By A Duo Or Group With Vocals: Stay, Sugarland, track from Enjoy the Ride (Mercury Records)
- R&B Album: Jennifer Hudson, Jennifer Hudson (Arista Records)
- Producer of the Year, Non-Classical: Rick Rubin
Producer of the Year, Classical: David Frost
- Female Pop Vocal Performance: Chasing Pavements, Adele, track from 19 (Columbia/XL)
- Traditional Pop Vocal Album: Still Unforgettable, Natalie Cole (DMI Records)
- Pop Vocal Album: Rockferry, Duffy (Mercury)
- Pop Instrumental Performance: I Dreamed There Was No War, Eagles, track from Long Road Out of Eden (Eagles Recording Company)
- Pop Instrumental Album: Jingle All the Way, Bela Fleck & The Flecktones (Rounder)
- Pop Performance by a Duo or Group with Vocals: Viva La Vida, Coldplay, track from Viva La Vida Or Death And All His Friends (Capitol Records)
- Alternative Music Album: In Rainbows, Radiohead (TBD Records)
- Solo Rock Vocal Performance: Gravity, John Mayer, track from Where The Light Is: Live in Los Angeles (Columbia)
- Rock Performance by a Duo or Group with Vocals: S** on Fire, Kings of Leon (RCA Records)
- Hard Rock Performance: Wax Simulacra, The Mars Volta (Universal Motown)
- Metal Performance: My Apocalypse, Metallica, track from Death Magnetic (Warner Bros.)
- Rock Instrumental Performance: Peaches En Regalia,Zappa Plays Zappa featuring Steve Vai and Napoleon Murphy Brock (Strobosonic/Razor & Tie Entertainment)
- Rock Song: Girls in Their Summer Clothes, Bruce Springsteen, songwriter (Bruce Springsteen), track from Magic (Columbia; Publisher: Bruce Springsteen)
- Rap Solo Performance: A Milli, Lil Wayne, track from Tha Carter III" (Cash Money/Universal Motown)
- Rap Performance by a Duo or Group: Swagga Like Us, Jay-Z and T.I. featuring Kanye West and Lil Wayne (Roc-A-Fella/Grand Hustle/Atlantic)
- Rap/Sung Collaboration: American Boy, Estelle featuring Kanye West, track from Shine (Homeschool/Atlantic)
- Rap Song: Lollipop, Dwayne Carter, Darius Harrison, James Scheffer, Stephen Garrett and Rex Zamor, songwriters (Lil Wayne featuring Static Major), track from Tha Carter III (Cash Money/Universal Motown; Publishers: Young Money Publishing/Warner-Chappell Music, Herbalicious Music/Blackfountain Music/EMI-April Music, JimiPub Music/EMI Blackwood, Three Nails and A Crown Publishing/Roynet Music)
- Country Song: Stay, Jennifer Nettles, songwriter (Sugarland), track from Enjoy the Ride (Mercury Records; Publisher: Jennifer Nettles Publishing)
- Country Album: Troubadour, George Strait (MCA Nashville)
- Female Country Vocal Performance: Last Name, Carrie Underwood, track from Carnival Ride (19/Arista/Arista Nashville)
- Male Country Vocal Performance: Letter to Me, Brad Paisley, track from 5th Gear (Arista Nashville)
- Country Collaboration with Vocals: Killing the Blues, Robert Plant and Alison Krauss, track from Raising Sand (Rounder)
- Country Instrumental Performance: Cluster Pluck, Brad Paisley, James Burton, Vince Gill, John Jorgenson, Albert Lee, Brent Mason, Redd Volkaert and Steve Wariner (Arista Nashville)
- R&B Song: Miss Independent, Mikkel S. Eriksen, Tor Erik Hermansen and Shaffer Smith, songwriters (Ne-Yo), track from Year of the Gentleman (Def Jam/Compound; Publishers: Pen in the Ground Publishing, Universal Music-Z Tunes)
- Contemporary R&B Album: Growing Pains, Mary J. Blige (Geffen)
- Female R&B Vocal Solo: Superwoman, Alicia Keys, track from As I Am (J Records)
- Male R&B Vocal Solo: Miss Independent, Ne-Yo, track from Year of the Gentleman (Def Jam/Compound)
- R&B Performance by a Duo or Group with Vocals: Stay With Me (By the Sea), Al Green featuring John Legend, track from "Lay It Down" (Blue Note Records)
- Traditional R&B Vocal Performance: You've Got the Love I Need, Al Green featuring Anthony Hamilton, track from Lay It Down (Blue Note Records)
- Urban/Alternative Performance: Be OK, Chrisette Michele featuring will.i.am, track from I Am (Def Jam)
- Dance Recording: Harder Better Faster Stronger, Daft Punk, Thomas Bangalter and Guy Manuel de Homem-Christo, producers; Thomas Bangalter and Guy Manuel de Homem-Christo, mixers; track from Alive 2007 (Virgin Records)
- Electronic Dance Album: Alive 2007, Daft Punk (Virgin Records)
- Bluegrass Album: Honoring the Fathers of Bluegrass: Tribute to 1946 and 1947, Ricky Skaggs and Kentucky Thunder (Skaggs Family Records)
- Traditional Blues Album: One Kind Favor, B.B. King (Geffen Records)
- Contemporary Blues Album: City That Care Forgot, Dr. John and The Lower 911 (429 Records)
- New Age Album: Peace Time, Jack DeJohnette (Golden Beams/Kindred Rhythm)
- Contemporary Jazz Album: Randy in Brasil, Randy Brecker (MAMA Records)
- Jazz Vocal Album: Loverly, Cassandra Wilson (Blue Note)
- Jazz Instrumental Solo: BE-BOP, Terence Blanchard, soloist; track from Live at the 2007 Monterey Jazz Festival (Monterey Jazz Festival 50th Anniversary All-Stars) (Monterey Jazz Festival Records)
- Jazz Instrumental Album Individual or Group: The New Crystal Silence, Chick Corea and Gary Burton (Concord Records)
- Large Jazz Ensemble Album: Monday Night Live at the Village Vanguard, The Vanguard Jazz Orchestra (Planet Arts Recordings)
- Latin Jazz Album: Song for Chico, Arturo O'Farrill and The Afro-Latin Jazz Orchestra (Zoho)
- Latin Pop Album: La Vida ... Es Un Ratico, Juanes (Universal Music Latino)
- Latin Rock or Alternative Album: 45, Jaguares (EMI Music)
- Latin Urban Album: Los Extraterrestres, Wisin y Yandel (Machete Music)
- Tropical Latin Album: Senor Bachata, Jose Feliciano (Universal Music Latino)
- Regional Mexican Album: Amor, Dolor y Lagrimas: Musica Ranchera, Mariachi Los Camperos de Nati Cano (Smithsonian Folkways Recordings) in a tie with Canciones de Amor, Mariachi Divas (Shea Records/East Side Records)
- Traditional Folk Album: At 89, Pete Seeger (Appleseed Recordings)
- Contemporary Folk/Americana Album: Raising Sand, Robert Plant and Alison Krauss (Rounder Records)
- Native American Music Album: Come to Me Great Mystery: Native American Healing Songs, (Various Artists) Tom Wasinger, producer (Silver Wave Records)
- Hawaiian Music Album: Ikena,Tia Carrere and Daniel Ho (Daniel Ho Creations)
- Zydeco or Cajun Music Album: Live at the 2008 New Orleans Jazz & Heritage Festival, BeauSoleil and Michael Doucet (MunckMix)
- Engineering Album, Classical: Traditions and Transformations: Sounds of Silk Road Chicago, David Frost, Tom Lazarus and Christopher Willis, engineers (Miguel Harth-Bedoya, Alan Gilbert, Silk Road Ensemble, Wu Man, Yo-Yo Ma and Chicago Symphony Orchestra) (CSO Resound)
- Reggae Album: Jah Is Real, Burning Spear (Burning Music Production)
- Traditional World Music Album: Ilembe: Honoring Shaka Zulu, Ladysmith Black Mambazo (Heads Up International)
- Compilation Soundtrack Album for Motion Picture, Television or Other Visual Media: Juno, (various artists) Peter Afterman, Jason Reitman and Margaret Yen, producers (Fox Music/Rhino)
- Score Soundtrack Album for Motion Television or Other Visual Media: The Dark Knight, James Newton Howard and Hans Zimmer, composers (Warner Sunset/Warner Bros.)
- Polka Album: Let the Whole World Sing, Jimmy Sturr and His Orchestra (Rounder)
- Gospel Performance: Get Up, Mary Mary; track from The Sound (Columbia)
- Contemporary R&B Gospel Album: The Fight of My Life, Kirk Franklin (Fo Yo Soul Entertainment/Zomba Gospel)
- Classical Album: Weill: Rise and Fall of the City of Mahagonny, James Conlon, conductor; Anthony Dean Griffey, Patti LuPone and Audra McDonald; Fred Vogler, producer (Donnie Ray Albert, John Easterlin, Steven Humes, Mel Ulrich and Robert Worle; Los Angeles Opera Chorus; Los Angeles Opera Orchestra) (EuroArts)
- Song Written for Motion Picture, Television or Other Visual Media: Down to Earth, (WALL-E) Peter Gabriel and Thomas Newman, songwriters (Peter Gabriel) (Walt Disney Records/Pixar; Publishers: Walt Disney Music, Wonderland Music/Pixar Talking Pictures/Pixar Music)